H2N2V1, Main, Exploration, bibRecord, 001815

Susceptibility and immunity to influenza A strains in Ig−/−mice

Identifieur interne : 001815 ( Main/Exploration ); précédent : 001814; suivant : 001816

Susceptibility and immunity to influenza A strains in Ig−/−mice

Auteurs : Kimberly A. Benton [États-Unis] ; Julia A. Misplon [États-Unis] ; Chia-Yun Lo [États-Unis] ; Suzanne L. Epstein [États-Unis]

Source :

International congress series [ 0531-5131 ] ; 2001.

RBID : ISTEX:2513BABB02ABDCB8CBD353591F4AE0234ABF8E47

English descriptors

Teeft :
- Animal models, Benton, Different subtypes, Dos, Heterosubtypic, Heterosubtypic immunity, High titers, Immunization, Immunol, Influenza, Influenza arbor, Influenza infection, Influenza strains, Influenza type, Influenza virus, Influenza virus infection, International congress series, Intraperitoneal immunization, Knockout mouse models, Lethal challenge, Lung titers, Lung virus, Lung virus titers, Mouse, Secondary infection, Subtypes, Vaccine, Virol, Virus clearance.

Abstract

Abstract: Background: Broad cross-protection to influenza strains of different subtypes, termed heterosubtypic immunity, can be observed in animal models and is the goal of new approaches to human vaccines. Knockout mouse models, such as doubly inactivated (DI) mice lacking B cells and Ig, can be used to focus on the role of T cells in heterosubtypic immunity. We previously demonstrated that DI mice immunized with influenza B/Ann Arbor were protected from homologous challenge. We wished to identify influenza A strains that could be used in DI mice to examine the contributions of T-cell subsets to heterosubtypic immunity. Methods: DI mice were infected intranasally (i.n.) under anesthesia with influenza strains at varying doses. Mice were monitored for mortality, and lung titers were assessed for non-lethal strains. Results: Commonly used mouse-tropic influenza A strains were lethal to DI mice, even at low doses. Several other isolates were found to replicate to high titers in the lungs for several days until being cleared to undetectable levels. Conclusion: Non-lethal strains that replicate in the lungs can be used to study heterosubtypic protection in DI mice measured as reduction in lung virus titers.

Url:

https://api.istex.fr/ark:/67375/6H6-RFDNJZ31-5/fulltext.pdf

DOI: 10.1016/S0531-5131(01)00343-0

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Background: Broad cross-protection to influenza strains of different subtypes, termed heterosubtypic immunity, can be observed in animal models and is the goal of new approaches to human vaccines. Knockout mouse models, such as doubly inactivated (DI) mice lacking B cells and Ig, can be used to focus on the role of T cells in heterosubtypic immunity. We previously demonstrated that DI mice immunized with influenza B/Ann Arbor were protected from homologous challenge. We wished to identify influenza A strains that could be used in DI mice to examine the contributions of T-cell subsets to heterosubtypic immunity. Methods: DI mice were infected intranasally (i.n.) under anesthesia with influenza strains at varying doses. Mice were monitored for mortality, and lung titers were assessed for non-lethal strains. Results: Commonly used mouse-tropic influenza A strains were lethal to DI mice, even at low doses. Several other isolates were found to replicate to high titers in the lungs for several days until being cleared to undetectable levels. Conclusion: Non-lethal strains that replicate in the lungs can be used to study heterosubtypic protection in DI mice measured as reduction in lung virus titers.</div>
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Susceptibility and immunity to influenza A strains in Ig−/−mice

Susceptibility and immunity to influenza A strains in Ig−/−mice

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri